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Posted: Thu May 22nd, 2008 05:22 |
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In order to help the study site nurse moderators interpret your D-Metabolites tests, please post the following information with your test results in this forum
http://curemyth1.org/forum5/
(click the "new Topic" button above ^).
Briefly list your diagnosis or symptoms. (around 2 lines at the most).
-The date the blood was drawn
-Which lab did the tests?
-Was the 1,25-D sample was frozen for shipment?
-How long have you been avoiding foods with vitamin D in them?
-How long have you been avoiding sun/lights?
-List all meds, supplements (both prescription and OTC) you have been taking and why.
-When and for how long have you taken prednisone or any other immunosuppressant in any form?
-When and for how long did you take Vitamin D supplements (including any vitamin-mineral supplements), omega-3 supplements and/or any kind of fish oil?
-Were you taking Benicar when the sample was drawn?
-Were you taking an ARB or or an ACE inhibitor when the sample was drawn?
- Please add the required signature line
When we analyze the results, we take all of the above into account.
Include the measurements for both tests, 1,25D & 25D, noting either ng/ml and pg/ml or the metric equivalent; nmol or pmol.* (ug/l = ng/ml)
Do not accept the term "normal range" for the results, we need the actual numbers.
It is helpful if you convert metric measurements to pg/ml and ng/ml.
Automatic:
You may convert your Vit D test results with this online calculator.
http://mp.behindthepage.com.au/
Manual:
You may convert metric D results using this formula:
1,25D (pmol/L) - divide pmol/L by 2.4 to convert to pg/ml
25D (nmol/L) - divide nmol/L by 2.5 to convert to ng/ml
Calculator
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Lab ranges
There is no need to include lab ranges for the D-metabolites tests.
1,25-D results that are within normal lab ranges may still be abnormal because high levels are not used to diagnose any illness. Therefore, lab ranges are determined without considering that a large percentage of patients getting this test are ill with undiagnosed Th1 inflammation, thus skewing the 1,25-D range upward. The Merck Manual 1,25-D range of 20-45 pg/ml is a more reliable indicator of the 1,25-D normal range.
Clinicians have yet to recognize the reason for low levels of 25-D and usually recommend supplementation with vitamin D. Thus, lab ranges for 25-D are being skewed higher and higher by the increasingly prevalent use of dietary supplementation.
See What Does a 'Normal Range' Mean?
D ratio
The D ratio is a guide to the amount of systemic Th1 inflammation based on the unaltered levels of 25-D (no supplementation of vitamin D) and accurate, measurement of 1,25-D (unaltered by medication). It is only meaningful under certain conditions before any of the aspects of the MP are started.
It was previously thought that a low 25-D indicated a rapid conversion of this pre-hormone to 1,25-D. Dr. Marshall's recent research found that high levels of 1,25-D inhibit the conversion of vitamin D into 25-D. Thus, the D ratio (ratio of 25-D to 1,25-D) is not a sufficient indicator of vitamin D dysregulation, especially when 25-D levels rise above 15 ng/ml. Moderators will base D ratio assessment on their knowledge of the complete metabolism.
Now that we know more about the molecular activity of vitamin D metabolism, the D ratio carries less significance. Pre-MP, it is an adequate clinical guesstimate of Th1 inflammation (but an inadequate scientific analysis) if it is able to be interpreted accurately. The D ratio has no value after the MP has begun.
How to obtain your lab results
Your doctor's office personnel can read you the exact numbers with measurements over the phone but we recommend you get a printed copy of the lab results. The clinic cannot give out this information until you sign a release of information form.
Call your clinic's "Release of Information Office" or Medical Records to find out what their procedure is to obtain medical records. You should be able to do this all via the phone and mail. Once your release form is on file, you can just call them and have them mail you copies of the doctor's clinic note and test results after each visit. A proactive patient knows exactly what is in his/her medical record.
If you would like us to comment on other lab tests, you must include the lab ranges in addition to the test result. See Policy regarding posting other lab test results.
For more information, please see: What do my lab tests mean?
If you have not yet tested, please review D-Metabolites tests
See also:
How often should I test D levels? What are the target numbers?
Measurement of D2 and D3
Do I need to get my 25-D down before I start the MP?
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