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Lind
Member
| Joined: | Sun Sep 21st, 2008 |
| Location: | Virginia USA |
| Posts: | 44 |
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Posted: Thu Oct 16th, 2008 00:53 |
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Symptoms: Chronic fatigue, migrating joint pain, numbness/tingling around eyes and one side of face. 25 yrs of GI issues presenting like Crohn's with ulcers, but biopsies negative. Heart arrhythmia. GI and heart problem followed infection that was probably systemic Lymes. Elevated liver enzymes two yrs. ago and rash on back and shin. No diagnosis.
-The date the blood was drawn 9/25/08
-Which lab did the tests? Quest
-Was the 1,25-D sample was frozen for shipment? They said it would be.
-How long have you been avoiding foods with vitamin D in them? Only 4 days when sample was drawn.
-How long have you been avoiding sun/lights? Not
-List all meds, supplements (both prescription and OTC) you have been taking and why. Have had short treatments with prednisone and doxycycline during last two yrs for inflammation. On Endocort and Pentassa for 4 months in late 2007 for GI ulcers. Prescribed 800 U of D in 8/06 until 8/08, then changed to 2000 U/ day for deficiency. Take advil for pain. Multi-vitamin/mineral supplement.
-When and for how long have you taken prednisone or any other immunosuppressant in any form? See above
-When and for how long did you take Vitamin D supplements (including any vitamin-mineral supplements), omega-3 supplements and/or any kind of fish oil? Have always taken a multi vitamin with 400 U D until Dr. increased dose. Main foods have been seafood, shellfish, mushrooms, pumpkin seeds and soy protein drink for about the last 20 yrs. Have taken either fish oil caps or flax seed supplement for about the same time and also took cod liver oil supplement in winter.
-Were you taking Benicar when the sample was drawn? No
-Were you taking an ARB or or an ACE inhibitor when the sample was drawn? No
1,25 Dihydroxy 31 pg/ml
D 25 Hydroxy 54 ng/ml
D2 < 4 ng/ml
Alkaline Phos 126 U/L ( 33 -130) Down from 176 U/L in 5/06
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Pre MP, Crohn's-like GI symptoms, Borreliosis, CFS,Fibromyalgia, MP diet, no UV protection 25D=54ng/ml. 1,25D= 31pg/ml.
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P.Bear R.N.
Research Staff
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Posted: Thu Oct 16th, 2008 04:28 |
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Lind,
Your 1,25-D is only slightly elevated at 31pg/ml (the population average is 25-29 pg/ml). It is 0.21 sigma high and based on population studies, 58.30% of the population would be expected to have a lower number.
Your 25-D of 54ng/ml is terribly high and reflects your reported very large amount of vitamin D supplementation. Because 25-D is immunosuppressive, you would need to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less if you want to fully enable innate immune function.. Please see Foods To Avoid and The importance of avoiding vitamin D.
Because 25-D is immunosuppressive, your high level of 25-D may have kept your 1,25-D low and therefore, your 1,25-D may not be an accurate reflection of your systemic inflammation.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Your D-tests are ambiguous, but your diagnosis and symptoms would seem to indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. If you have a chronic infection you will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease? Since your very high level of 25-D may well be masking a more significant inflammation that is the rule in CFS, You might want to avoid dietary D and sunlight on skin and stop the higher dose supplements for some time and retest the 1,25-D and 25-D. To do a therapeutic probe at this point may be inconclusive since you have managed to mute most innate immune response by taking so much of the seco-steroid D. You have the option of trying one once your 25-D levels have dropped to a more reasonable level.
As you know your previous elevation in Alk Phos would indicate some liver involvement at least at that time, that may be currently masked by your partially immuno-suppressed state.
Most supplements and many medications must be avoided on the MP.
Our clinical study is closed to enrollment.
best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Lind
Member
| Joined: | Sun Sep 21st, 2008 |
| Location: | Virginia USA |
| Posts: | 44 |
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Posted: Thu Oct 16th, 2008 11:53 |
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| Thank you for your quick response! I have now been off of vitamin D for about 4 weeks. I am feeling awful with all sorts of inflammation. Have I been off of vit D long enough for this to be a valid therapeutic probe?
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Pre MP, Crohn's-like GI symptoms, Borreliosis, CFS,Fibromyalgia, MP diet, no UV protection 25D=54ng/ml. 1,25D= 31pg/ml.
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P.Bear R.N.
Research Staff
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Posted: Thu Oct 16th, 2008 21:15 |
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Lind, Your increased inflammation is significant evidence that the D3/25-D was apt to be functioning as an immunosupressant in your case as suspected. Although you have not tested really elevated in your 1,25-D yet, we do know that Benicar is protective of the heart, kidneys, liver and other organs and may help many people as they wean form steroids or in your case seco-steroids. If your physician is willing to prescribe the correct dose of the Benicar it could be well worth the trial if you are also ready to protect your eyes and skin from sunlight. Would recommend reading all the essentials and FAQs on MP site first, and asking your doc to join proffessionals forum if this is within the realm of the possible.
best ,P.B.
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Lind
Member
| Joined: | Sun Sep 21st, 2008 |
| Location: | Virginia USA |
| Posts: | 44 |
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Posted: Fri Oct 17th, 2008 00:14 |
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| Thank you. I will talk to my doctor about starting Benicar. I was waiting to order Noirs depending on my metabolites test. I'll have to get busy. Thanks again.
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Pre MP, Crohn's-like GI symptoms, Borreliosis, CFS,Fibromyalgia, MP diet, no UV protection 25D=54ng/ml. 1,25D= 31pg/ml.
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