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cbeachinn
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| Joined: | Sat Sep 27th, 2008 |
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Posted: Sat Sep 27th, 2008 15:37 |
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No one has a clue and I'm very ill--have been for two years since I had hernia surgery.
They first called it an anesthesia reaction--then panic attacks--now dysautonomia. None of this tells me anything. I sleep 4 hours--then wake up shaking, sweating, nausea, and often disoriented. My pulse races, BP drops pulse 140 BP 70/40. So I got beta blockers--pulse dropped to 50's BP hit 171/151 (usually it's 120/80 pulse 72)
Endo is stumped--cardio shows MVP and borderline abnormals stress. Neuro workup was unremarkable. Psyche shows memory loss, and slow reaction time--no other abnormalities. Mult sleeping aids have been of no use.
Norenephrine levels are running very high--but no adrenal tumor. I'm very ill and weak.
First D test was done3/27/08 by Quest--I have no idea if sample was frozen or not in any of these cases--but I'd guess no since I never saw anything hit the fridge.
D25 -OH, total--33ng/ml (showed within normal range)
D,25-oh,D3 was 33ng/ml
D25-OH,D2was 0
D125 dihydroxy of the same date showed 86 pg/ml(read high)
Later when dexi scan revealed osteoporosis at a -3.5 in my spine the test were run again.
5/15/08 Test run by LabCorp Birmingham ALA
D, 125 dihydroxy 45.6 pg/ml (normal)
D25 hydroxy 23.1 ng/ml (showed low)
At this point I was prescribed 50,000 Units of D2 per week with 1,500 units of calcium per day. Took the first 50,000 D pill and purged violently. Doc said this was impossible keep taking it. Continued by doing 30 min of sun per day when it was out that day--and taking d-2 7,000 units per day with calcium as prescribed.
At first I felt better, then began getter sicker again--then MUCH sicker. Did not have an endo follow up scheduled for 2 months so went to a GP.
6/19/08 Retest D levels post vitamin and sun therapy
D-125 dihydroxy Quest--50pg/ml (normal)
D 25 hydroxy 57ng/ml--57 ng/ml (normal)
B-12 tests also taken--I'm feeling very tired and sick. 275 (says in normal range)
Was told I was now cured. Nothing wrong with me. I felt like crap. Started seeing docs at the Cleveland clinic. Started B-12 treatment--felt better a day or two--then worse again. Tried folic acid--made me sicker too.
Vision blurred, ears ring, feel wired for no reason, dizzy, weak, tired, can't sleep beyond 4 hours tho I fall out cold to go to sleep VERY easily and am very tired. Nose runs for no reason--allergic to everything all of the sudden.
I could go on--but the list would fill a book. Feels like my body is falling apart--and my brain is in a dense fog. My personality is all over the map for no reason. Herpes sores crop up often and are slow to heal, mult UTI's also slow to heal. Blood sugar is all over the map--can't touch sugar or I pass out soon afterwards--but also get sick if I don't eat often. Get stomach burning from toast at times. My home life is fine--married--husband is being very supportive tho it's been two years.I love him--and he me. We'll be married 30 years next week.
Do I fit your profile? If so it'll be the FIRSt one I seem to fit.
Thanks for reading this--IF you did.
Sandra Sims,Cape Coral,Fl.
Last edited on Sat Sep 27th, 2008 15:37 by cbeachinn
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P.Bear R.N.
Research Staff
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Posted: Sun Sep 28th, 2008 04:24 |
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Sandra, I am sorry you have been though such a bad run around. This is pretty common in TH1 Illness where most medical providers just don't have clue about how sick you really are or how to help you. Having you take D was about the worst thing they could have done for you and reveals the ignorance of most clinicians in understanding D metabolism, chronic TH1 infection and osteoporosis. I will analyze the 3/27/08 lab from Quest. Labcorps can not be trusted to do the test properly as is clearly indicated by your May results. Your repeat Quest labs reveal that your D supplementation had elevated your 25-D to a terribly high level that in turn reduced your 1,25-D level somewhat (but still a bad level) by acting as the seco-steroid that it is.
3/27/08 results:
Your 1,25-D is terribly elevated at 86pg/ml (the population average is 25-29 pg/ml). It is 6.00 sigma high and based on population studies, 100% of the population would be expected to have a lower number.
Your 1,25-D is above the maximum of 45pg/ml listed in the Merck Manual of Diagnosis and Therapy (15 Oct 2006 online). At levels above about 42 pg/ml, the 1,25-D (generated by the Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissue of the body, including the lungs, breasts, and the kidneys (where it forms kidney stones). Please see Osteoporosis, osteopenia and Th1 illness.
Your level of elevation suggests inflammation in major organs such as the heart, liver and lungs.
When should I be concerned about cardiac symptoms?
Your 25-D of 33ng/ml is high and reflects your reported vitamin D supplementation. Because 25-D is immunosuppressive, you need to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Your D-tests, diagnosis and symptoms clearly indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. You will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP.
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application form, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line. You very clearly fit the profile of one with a TH1 infection.
Best, P.B.
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Dr Trevor Marshall
Research Team
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Posted: Sun Sep 28th, 2008 21:12 |
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Sandra,
If you look at my response to the second question from the audience following my Porto presentation, you will see that I emphasize that people only get diagnosed as being sick when they fit some diagnosis criteria. I mention Chronic Fatigue as an example of an emerging physiological diagnosis. As PB says, your D metabolites clearly show immune dysfunction, it is just that Medicine will take another couple of decades to begin to understand that. The instant communication given to us by the Internet should help us accelerate that considerably.
http://vimeo.com/1787405
You might also like to review Cpt Tom Perez's presentation transcript at
http://AutoimmunityResearch.org/transcripts/ICA2008_Transcript_TomPerez.pdf
or the video at
http://vimeo.com/1789735
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