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KayJ
Member
| Joined: | Thu Aug 7th, 2008 |
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| Posts: | 12 |
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Posted: Tue Sep 9th, 2008 06:58 |
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He is 10 years old. He has Crohn's, lyme ,seizures, tics, light sensitivity, badly chapped lips etc. Has high levels of serum IL-2, IL-12 and INF gamma among others.
Blood drawn : 8/13/2008
Quest
Sample frozen
Not avoiding Vitamin D foods nor consciously consuming as he is only on foods he can tolerate.
Not avoiding sunlight
No meds or supps
Took MethylPrednisolone shots 2 months ago for his Crohn's for 6 weeks.
Has been on 30% RDA D3 with calcium on and off.
No Benicar yet
No ARB or ACE inhibitor
Vitamin D, 25-OH , Total 11 Ref range 20 -100 ng/mL
Vitamin D, 1,25-D 50 Ref range 27 - 71 pg/mL
ACE 40 Ref range 13 - 100 u/l
Thank you
J
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10 year old son with Crohn's, lyme and autism diagnosis and had high Th1 cytokines. Started Benicar Nov 9th 2008 at 20mg 6 times a day
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P.Bear R.N.
Research Staff
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Posted: Tue Sep 9th, 2008 07:17 |
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J,
1,25-D is elevated at 50pg/ml (the population average is 25-29 pg/ml). It is 2.21 sigma high and based on population studies, 98.65% of the population would be expected to have a lower number.
His 1,25-D is above the maximum of 45pg/ml listed in the Merck Manual of Diagnosis and Therapy (15 Oct 2006 online). At levels above about 42 pg/ml, the 1,25-D (generated by the Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissue of the body, including the lungs, breasts, and the kidneys (where it forms kidney stones). Please see Osteoporosis, osteopenia and Th1 illness
25-D of 11 ng/ml is low for someone who has been supplementing with vitamin D. Because 25-D is immunosuppressive, he still needs to avoid ALL sources of Vitamin D to keep it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Your son's D-tests, diagnosis and symptoms indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. He will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP.
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
Best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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