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Cynthia Schnitz
Member
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Posted: Wed Aug 27th, 2008 07:47 |
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Symptoms: Arthritis(spondylitis?), Calcium anomaly(recently noted Vit-D related), Type II diabetes(unconfirmed), disabled sense of smell, Candidiasis, toenail fungus, sitting produces chilled state, occasional & inexplicable(till now) feeling of intoxication
Test results just received: 25-D 43 ng/ml 1,25-D 47 pg/ml Quest lab, believe was properly handled, blood drawn 8-11-08
Test result 2 years ago: 25-D 34 ng/ml
Low carbohydrate regimen last 6 years
Meds: Bio-identical hormones (Progesterone - 200 mg tpd, Tri-Estrogen - 1.25 mg [80,10,10] tpd), Nystatin for intestinal Candida since 1993, mostly unused since low carb diet, but used a few times around time of test. Undecylenic acid topically for toe-nail fungus last year or two. No other meds.
Supplements: for many years, full range of supplements (not one a day), including, Vit.-D (300 to 1000 IU, averaging around 400-500 IU), DMAE (150 mg), DHEA (25 mg), Soy extract (185 mg), Folic Acid (200 to 1200 mcg, averaged ~400 mcg), AND
Last 11 years, 6 capsules (1100 mg ea) Omega 3 fish oil, reduced to 4 caps last few years (low carb diet reducing need?), and 6 tabs Glucosasmine/Chrondroitin (500/400 mg), reduced to 4 pd last few years.
6 weeks before tests: Vit-D removed from diet, with improving efficacy over period, dropped all supplements except: vegan glucosamine, 3 caps (750 mg), Perilla Oil. 4 caps, reduced to 2 over period (1000 mg, vegetable source of Omega 3), moderate sun avoidance.
2 weeks before tests: Dropped glucosamine and progesterone, with perilla Oil at 1 cap pd and as needed. Toenail med dropped.
I think something should be said about the history of my arthritis. No one ever said what kind of arthritis it is. I was diagnosed in 1991 by changes seen on an xray. It is not osteoarthritis, as I have always had excellent bone density tests. It appears to be limited to swelling in the pads of my back and definitely has an immune connections, as I once tried to be smart, and gathered up every supplement known to have anything to do with the immune system to try to correct the problem. Taking these caused a disaster. It turned up the fires of hell and a year later, around the time I discovered Omega 3 oils, I had a mildly herniated disk, and tissues so stretched that a vertebrae kept popping out of place, and plenty of misery. Since the use of Omega 3 oils to keep the inflammation/swelling down, all of the problems are gone, but my back always tells me when I am not taking enough Omega 3 oil.
Now that I have been off vitamin D for 2 months, I am down to an occasional perilla oil cap, and I am about where I was before that big mistake. So, is it possible that the low carb diet has killed off all the sugar dependent cwd bacteria, easing that particular problem? Big question, since my 25-D is so high, and my symptoms are quite manageable right now, would it be best to wait on the full protocol, and just work on getting the 25-D down, with a 25-D test every 2 or 3 months, until my 25-D gets close to 20 ng/ml?
I am also a little concerned that other cwd bacteria may now be filling the void. I have had some indication that my teeth are not as sturdy as before, with some chipping and etching in the last couple of years. I will have another bone density test very soon, and if I am now starting to show bone density loss, I guess I will come back for suggestions for more immediate help.
Just a note about the Calcium anomaly. It is a very brief sensation of electricity running thru my body. At one point, this was the regular symptom two or three hours after consuming any source of calcium. This appeared to finally ceased happening with calcium until one day, after milk was added back into my diet, I took a single large dose of vitamin D, producing a large such sensation. I think I will not be able to get all the way up to the RDA of calcium for awhile until this passes, as it comes back with the RDA dose of calcium, but is not really noticeable with about half of that.
Cynthia
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Phase I 10-27-08, Calcium anomaly causes sensation of electricity thru chest, Spondylitis, TypeII diabetes(unconfirmed), returning sense of smell, sitting produces chilled state, finger ulcers
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P.Bear R.N.
Research Staff
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Posted: Wed Aug 27th, 2008 18:36 |
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Cynthia,
Your 1,25-D is elevated at 47pg/ml (the population average is 25-29 pg/ml). It is 1.89 sigma high and based on population studies, 97.05% of the population would be expected to have a lower number.
Your 1,25-D is above the maximum of 45pg/ml listed in the Merck Manual of Diagnosis and Therapy (15 Oct 2006 online). At levels above about 42 pg/ml, the 1,25-D (generated by the Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissue of the body, including the lungs, breasts, and the kidneys (where it forms kidney stones). Please see Osteoporosis, osteopenia and Th1 illness.
Your 25-D of 43ng/ml is very high and reflects your reported vitamin D supplementation. Because 25-D is immunosuppressive, you need to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Because 25-D is immunosuppressive, your high level of 25-D may have kept your 1,25-D low and therefore, your 1,25-D may not be an accurate reflection of your systemic inflammation.
Your D-tests, diagnosis and symptoms indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. You will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP. It seems like your body believed what the bacteria was telling it, as the supplements you were on were perhaps the worst ones possible for you but tailor made for CWD growth. As you may know glucosamine may help the growth of CWD forms. The low carb diet may have helped somewhat but you will still be full of carb loving CWD forms.
I might be wary of the purported effects of perilla Oil, as the below study indicated that mice died much sooner on perilla oil than on safflower oil even with lower aging scores. It seems the perrila oil group tended to die of other causes before they could die of cancer. Although we are not mice I might be concerned as there may be other bioactive compounds in perilla oil besides omega 3s.
see #27 in:
http://www.lef.org/magazine/mag2000/oct2000_medup.html
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
Best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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