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robbo1
Member
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Posted: Mon Aug 25th, 2008 11:06 |
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Hi. Just received my vitamin D test results from my doctor. My 25-D level is 8.8ng/ml and 1,25-D is 32.9pg/ml. The samples were not frozen for shipment. My neutrophils count is down slightly, at 1.8 x10^9/L (2.0 - 7.5), triglycerides are elevated at 3.1 mmol/L (0.5 - 1.7) and my DHEAS is down at 1.6umol/L (2.5 - 13). I have been extremely fatigued for twelve years, with a sometimes debilitating brain fog, severe muscle and joint pain, short term memory problems and an inability to concentrate. I have had two appointments with my MP aware doctor and am hoping you can shed some light on my situation. Thank you for your time.
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CFS for 12 years, benicar 40mg 6hourly, minocycline 100mg every second day, noir glasses
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P.Bear R.N.
Research Staff
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Posted: Mon Aug 25th, 2008 18:11 |
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Rob,
High levels of 1,25-D inhibit the conversion of vitamin D into 25-D resulting in a low level of 25-D. Your 25-D of 8.8ng/ml is quite low for someone who has not been avoiding ALL sources of Vitamin D. This suggests that your actual 1,25-D is high and the measurement of 32.9pg/ml is a false low. The likely reason is sample mishandling. The population average is 25-29 pg/ml and it is above-average 1,25-D levels (hypervitaminosis-D) that cause many troublesome symptoms. Since you report many troublesome symptoms, either the lab result is in error or your paracrine (tissue) level of 1,25-D is much higher than the measured serum level. This sometimes occurs when the inflammation is in tissues not well perfused by blood (for example nerves, joints, skin).
Because 25-D is immunosuppressive, you still need to avoid ALL sources of Vitamin D to keep it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Your labs that are out of range are typical of your diagnosis. We strongly recommend not to take DHEA or other steroids or seco-steroids.
Your D-tests, diagnosis and symptoms indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. You will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP.
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
Best,
P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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robbo1
Member
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Posted: Tue Aug 26th, 2008 03:32 |
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Thank you for your reply. I actually registered on the marshallprotocol.com website while gathering information and in the meantime, my understanding is that the site has closed to new members. Unfortunately things do move very slowly and I'm unsure what my next step should be. I've therefore registered on this forum as well. I sent my doctor a copy of your reply and I believe he may be waiting for a more definative answer, as he is probably used to the marshallprotocol.com approach. I hope you can help me choose a coarse throgh this. I'm very confused by what step to take next. This brain fog doesn't help matters either. Thank you again for your time.
Anthony Robertson
Noted
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CFS for 12 years, benicar 40mg 6hourly, minocycline 100mg every second day, noir glasses
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robbo1
Member
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Posted: Mon Oct 6th, 2008 08:49 |
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Hi
I've been taking Benicar for three weeks now, 40mg every six hours. On Thursday I began to take minocycline 25mg, every two days. I have taken my third dose today. When just taking Benicar, I noticed that I was feeling noticeably more fatigued and my legs felt quite sore. I prepared myself for the worst when starting my minocycline but apart from feeling a little more fatigued again, there has been no real IP syptoms as yet. Is this to be expected? I'm sure when I up my dose to 50mg things will probably change. Any thoughts would be appreciated. Thanks for your time.
Anthony
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CFS for 12 years, benicar 40mg 6hourly, minocycline 100mg every second day, noir glasses
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P.Bear R.N.
Research Staff
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Posted: Tue Oct 7th, 2008 20:54 |
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Anthony, Since the clinical study is closed, you might want to post this on:
Non-medical support for those on MP or talk to your physician. Also read other's threads at:
Benicar and Minocycline Forum
and read all of:
Essential Information About the MP (Required Reading)
Marshall Protocol FAQs (Required Reading)
best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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