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Sreamer
Member
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Posted: Thu Aug 14th, 2008 19:08 |
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Jackson: age 7, suspected immune-mediated neurodegenerative disorder. Onset of symptoms around 12 -15 months of age, all normal developmental milestones met prior. Condition started as generalized weakness in lower extremities plus gastrointestinal distress. Progressed to significant hypotonia then on to nearly complete rigidity and inability to move, speak, or chew over a period of 18-24 monthsfrom legs to trunk to neck. Intermittent low grade fevers, ongoing extreme fatigue and inability to sleep, as well as a bout of pancreatitis that did not respond to total parental nutrition but did respond to the antifungal diflucan were noted. Severe, global developmental delay (physical rather than mental - sub 5% threshold for his age group in terms of weight/height). Subsequent infectious, metabolic, and neurological investigation revealed no abnormalities. Parents able to mediate whatever process was underway and for last 3 years has been stable neurologically (not getting worse, not getting better). Immunological tests below remain only consistent abnormal result. Background: Mother – who is highly allergic to penicillin, mistakenly received does of amoxicillin during labor and post labor suffered from anaphylaxis for several days and was administered high dose steroids for 6 weeks and continued to breast feed solely. Jackson’s condition became apparent after mother discontinued breastfeeding around 12 months of age.
Abnormal test/imaging results as/of March 2007
CSF Neopterin: 247 nM – high (ref range 7-65)
CSF Biopterin: 89nM – high (ref range 20-58)
C-Reactive Protein, quantitative: 1.34 – high
White blood count: 12.8 K/uL – high
Neutrophile count: 6.7 K/uL – high
Immune Complexes C1Q & RAJI: RAJI-equivalent CIC (ref range 0-15): 52.4 – high
Lymph tests:
%CD8: 40.9% - high (ref 16-30)
Absolute CD8: 2052 cells/uL – high (ref range 490-1300)
%CD3: 80.1% - high (ref range 56-75%)
Absolute CD3: 4019 cells/uL – high (ref range 1400-3700)
%Cd16/56: 3.6% – low (ref range 4-19%)
CD4/CD8 ratio: 0.94 – low (ref range 1.0-3.2)
CD3+/HLA-DR+: 33.2% - high (control 17.6%)
CD3+/CD25+: 9.0% - low (control 56.8%)
Hepatic function
AST, serum: 59 IU/L – high (ref range 22-44)
ALT, serum: 65 IU/L – high (ref range 12-34)
Brain CT scan & MRI in 2003: symmetric bilateral basal ganglia calcification, periventricular white matter calcification: stable as of 2007 upon subsequent MRI
Vitamin D tests as of August 1st 2008:
1,25-dihydroxy: 51 pg/mL
25-hydroxy: 55 ng/mL
D3: 55 ng/mL
D2: <4 ng/mL
Sample was frozen, testing lab was Quest.
Normal serum results for the following tests:
RBC
HGB
HCT
MCV
MCH
MCHC
HCT/HGB ratio
RDW
Platelet count
Mean platelet volume
Albumin
Total bilirubin
Direct bilirubin
Total protein
Alkaline phosphatase
ALB/GLOB ratio
Ferritin
Blood urea nitrogen
C3 level
C4 level
Calcium
ANA pattern X
Erythrocyte Sed rate
Phosporous
Glucose
Electrolytes
Creatinine
IgA serum level
IgG serum level
IgM serum level
Have started on Benicar 6 days ago, reduction of sunlight/Vit D 2 weeks ago and changes thus far are massively increased appetite (3-5 times more calories) and better sleeping at night.
Anyone care to interpret the D tests?
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P.Bear R.N.
Research Staff
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Posted: Thu Aug 14th, 2008 20:26 |
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Sreamer,
Your son's 1,25-D is elevated at 51pg/ml (the population average is 25-29 pg/ml). It is 2.32 sigma high and based on population studies, 99% of the population would be expected to have a lower number.
His 1,25-D is above the maximum of 45pg/ml listed in the Merck Manual of Diagnosis and Therapy (15 Oct 2006 online). At levels above about 42 pg/ml, the 1,25-D (generated by the Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissue of the body, including the lungs, breasts, and the kidneys (where it forms kidney stones). Please see Osteoporosis, osteopenia and Th1 illness. This may have been responsible for the "symmetric bilateral basal ganglia calcification, periventricular white matter calcification"
Your son's 25-D of 55ng/ml is very high and reflects a probable vitamin D supplementation. Because 25-D is immunosuppressive, he needs to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
I do not feel qualified to comment on immune function lymph tests, but his elevations in C-reactive protein and white and neutrophil counts, AST and ALT would be consistent with infection.
Your child's D-tests, diagnosis and symptoms indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. He will not get well and his health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP.
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
Best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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