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ronsotoo
Member
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Posted: Mon Aug 11th, 2008 23:01 |
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Hello everyone, I want to thank DR. Marshall, Meg Mangin, Amy Proal,
P. Bear, and all advocates and the volunteer here for their help and hard work.
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Psoriatic Arthritis joint skin inflammation 125D47 ph1SEPT08 25D22 NoIRs limited light exp only commute to work cover up low lux home
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ronsotoo
Member
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Posted: Mon Aug 11th, 2008 23:06 |
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Diagnosis or symptoms : Psoriatic Arthritis, poor concentration / memory, ‘brain fog’, extreme joint pain and inflammation, fatigue, stiffness in joints and scaly skin in two area on feet 1.5 inches in diameter.
Blood drawn: July 07, 2008
-Which lab did the tests? Quest Diagnostics
-Was the 1,25-D sample was frozen for shipment? Yes the sample was frozen
Test date 7/7/2008 4/2008 1/2008 9/07 5/07 10/06
Vitamin D, 1,25- 47 pg/ml
Vitamin D, 25- 22 ng/ml 36.2 ng/ml* 14.5 ng/ml 20.5 16.8 28.2
*I took two capsule of Vitamin D 1.25MG softgel pli on date March, 2008.
Test date 7/7/2008
Vitamin D, 25-OH, D3 15 ng/ml
Vitamin D, 25-OH, D2 7 ng/ml
Test date 07/2008
Creatinine 1.2 Mg/dl
Urea/Bun 19.1 Mg/dl
Albumin 4.2 g/dl
Calcium 8.9 Mg/dl
Erythrocyte SED Rate 2 mm/hr
C reactive Protein 1.4 MG/L
Complement C3 102 MG/DL
Complement C4 39 MG/DL
Free T-4 1.5 NG/DL
FreeT-3 3.2 PG/ML
TSM 1.61 UIU/ML
IMMUNOGLOBIN A (IGA) 510.7 MG/DL
IMMUNOGLOBIN A (IGG) 1167 MG/DL
IMMUNOGLOBIN M (IGM) 39 MG/DL
-How long have you been avoiding foods with vitamin D in them? Two month
-How long have you been avoiding sun/lights? Two month but I had to go to work and back, 1.5 hours a day.
-List all meds, supplements (both prescription and OTC) you have been taking and why.
Enberl 50 mg once a week, for about 2 years
lipitor 10 mg once a day, for about 1 year
baby asprin 81 mg once a day, 2 years
Avalide 150-12,5 mg, for blood pressure, 6 month other medication for blood pressure before.
-When and for how long have you taken prednisone or any other immunosuppressant in any form? From 2004 to 2005 I had mulite Prednisone injection on the different joint.
-When and for how long did you take Vitamin D supplements (including any vitamin-mineral supplements), omega-3 supplements and/or any kind of fish oil?
I had two capsule of Vitamin D 1.25MG soft gel pli on March 2008, and eat salmon two times from 1-1-2003 to 7-1-2008.
-Were you taking Benicar when the sample was drawn? No
-Were you taking an ARB or or an ACE inhibitor when the sample was drawn? I do not think, All medication list aboveLast edited on Mon Aug 11th, 2008 23:10 by ronsotoo
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Psoriatic Arthritis joint skin inflammation 125D47 ph1SEPT08 25D22 NoIRs limited light exp only commute to work cover up low lux home
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P.Bear R.N.
Research Staff
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Posted: Wed Aug 13th, 2008 06:43 |
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Ron,
Your 1,25-D is elevated at 42pg/ml (the population average is 25-29 pg/ml). It is 1.37 sigma high and based on population studies, 91.45% of the population would be expected to have a lower number. This number would be expected to be much higher if you were not on the ARB Irbesartan and the immune suppressing Enbrel.
Your 1,25-D is near the maximum of 45pg/ml listed in the Merck Manual of Diagnosis and Therapy (15 Oct 2006 online). At levels above about 42 pg/ml, the 1,25-D (generated by the Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. Not only does this lead to osteoporosis, but also to calcium being deposited into soft tissue of the body, including the lungs, breasts, and the kidneys (where it forms kidney stones). Please see Osteoporosis, osteopenia and Th1 illness.
Your 25-D of 22 ng/ml is high enough to mute innate immune response and reflects your reported vitamin D supplementation. Because 25-D is immunosuppressive, you need to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
"The 25-D seems to be the most critical factor as to whether the immune system is able to start working. Any level of 25-D above about 20ng/ml is likely to be acting as an immunosuppressant, with an action very similar to that of corticosteroids." Dr. Trevor Marshall, Ph.D.
Your D-tests, diagnosis and symptoms indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. You will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
Most supplements and many medications must be avoided on the MP. Avalide (Irbesartan-Hydrochlorothiazide) would need to be stopped when Benicar is started. Hydrochlorathiazide is too hard on the kidneys in our experience and Irbesartan is an ARB like Benciar but without the proper affinty profile that would be replaced by the higher dose Benicar. Lipitor is contraindicated.
You must include reference ranges for non D labs if you wish me to comment.
Policy regarding posting lab test results
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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ronsotoo
Member
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Posted: Wed Aug 13th, 2008 14:25 |
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Would you please review and comment, reference ranges for non D labs are included, let me know if you need other test result that provide more information.
Also would please review and comments on the previous D test tabulated,
Thank you
Test date 7/7/2008 4/2008 1/2008 9/07 5/07 10/06
Vitamin D, 1,25- 47 pg/ml
Vitamin D, 25- 22 ng/ml 36.2 ng/ml* 14.5 ng/ml 20.5 16.8 28.2
*I took two capsule of Vitamin D 1.25MG softgel pli on date March, 2008.
Test date 7/7/2008
Vitamin D, 25-OH, D3 15 ng/ml
Vitamin D, 25-OH, D2 7 ng/ml
Test date 07/2008 Reference range
Creatinine 1.18 Mg/dl 0.5-1.30 Mg/dl
Urea/Bun 19.1 MG/dl 7.0-20.0 MG/dl
Albumin 4.2 G/dl 3.5-5.3 G/dl
Calcium 8.9 Mg/dl 8.2-10.7 Mg/dl
Erythrocyte SED Rate 2 mm/hr 0-15 mm/hr
C reactive Protein 1.4 MG/L 0-5 MG/L
Complement C3 102 MG/DL 90-180 MG/DL
Complement C4 39 MG/DL 10-40 MG/DL
Free T-4 1.5 NG/DL 0.8-1.8 NG/DL
FreeT-3 3.2 PG/ML 2.3-4.2 PG/ML
TSM 1.61 UIU/ML 0.27-4.2 UIU/ML
IMMUNOGLOBIN A (IGA) 510.7 MG/DL 70-400 MG/DL
IMMUNOGLOBIN A (IGG) 1167 MG/DL 700-1600 MG/DL
IMMUNOGLOBIN M (IGM) 39 MG/DL 40-230 MG/DL
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Psoriatic Arthritis joint skin inflammation 125D47 ph1SEPT08 25D22 NoIRs limited light exp only commute to work cover up low lux home
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P.Bear R.N.
Research Staff
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Posted: Wed Aug 13th, 2008 21:59 |
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Ron, Your labs all look good except the CRP (C reactive protein) that would be further indication of chronic inflammation. Your thyroid glands seem to be working well. I am not experienced in looking at IMMUNOGLOBIN panels to give an opinion on the shift.
Your history of variable 25-D results is to be expected due to to several factors like sun exposure, food intake and the level of 1,25-D that will down regulate 25-D levels when it (1,25-D) is elevated. 1,25-D levels will shift somewhat throughout the day as a normal occurance and also as your irbesartan tissue effects wear off each day; and may also contribute to some fluctuations in daily 25-D levels.
best, P.B.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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