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lokesh
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| Joined: | Sun Jul 27th, 2008 |
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| Posts: | 5 |
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Posted: Tue Aug 5th, 2008 21:35 |
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list your diagnosis or symptoms – Fatigue, Energy less, Memory loss some time, Depression, Hyper tension , Difficult to get up in the morning,
[size= ]The date the blood was drawn – 31/07/2008
-Which lab did the tests? – Ranbaxy India
-Was the 1,25-D sample was frozen for shipment? - Yes[size=
]-How long have you been avoiding foods with vitamin D in them? – Not Yet
-How long have you been avoiding sun/lights? – 2-3 Yrs
-List all meds, supplements (both prescription and OTC) you have been taking and why. – hyroxin 25 mcg - since last 6-8 weeks
-When and for how long have you taken prednisone or any other immunosuppressant in any form? – Prednisone (60 mg per day) was taken for 6 weeks in May 2007 - June 2007 due to Nephrotic Syndrome.
-When and for how long did you take Vitamin D supplements (including any vitamin-mineral supplements), omega-3 supplements and/or any kind of fish oil? – Can’t remember
[size=
]-Were you taking Benicar when the sample was drawn? - No
-Were you taking an ARB or or an ACE inhibitor when the sample was drawn? - No
25 HYDROXYVITAMIN D - 7.03 ng/ml
1, 25 DIHYDROXY VITAMIN D3 - 15.1 pg/ml
BLOOD UREA NITROGEN, SERUM - 6.0 mg/dL
[size=ALKALINE PHOSPHATASE, SERUM - 85.0 U/L]
[size=CREATININE, SERUM - 0.7 mg/dL]
[size=TRIGLYCERIDES, SERUM - 118 mg/dL]
[size=CRP, SEMIQUANTITATIVE, SERUM - < 6 mg/L]
[size=T3 148.0 ng/dl]
[size=T4 9.0 μg/dl]
[size=TSH 4.78 μIU/ml]
[size=WHITE BLOOD CELLS - 6.7 thou/μL]
[size=SEGMENTED NEUTROPHILS - 53 %]
[size=EOSINOPHILS - 02 %]
[size=LYMPHOCYTES - 38 %]
[size=MONOCYTES - 07 %]
[size=BASOPHILS - 00 %]
[size=BAND (STAB) CELLS - 00 %]
[size=DIFFERENTIAL COUNT PERFORMED ON:EDTA SMEAR]
[size=HEMOGLOBIN - 13.0 g/dL]
[size=HEMATOCRIT - 37.4 %]
My wife was also diagnosed with Hypo Thyroidism last month. Her TSH value was 8.38 and T4 was 7.1 in June 08. Doctor in india has put her in Thyroxin 25 mcg 6-7 weeks ago. T4 and TSH level is normal now.
Rheumatologist in india has diagnosed lupus on base of the test reports of Ranbaxy lab and has asked her to take MMF 1.5 gm per day.Now we are in a dilemma and are unable to decide if we should start the medication or not.
Below are the tests which Rheumatologist did –
ANTIBODIES TO EXTRACTABLE NUCLEAR ANTIGENS
RHEUMATOLOGY PROFILE2
SMITH ABS IMMUNOBLOT NOT DETECTED
U1 SNRNP ABS IMMUNOBLOT POSITIVE
SSA ABS IMMUNOBLOT NOT DETECTED
SSB ABS IMMUNOBLOT POSITIVE
ANTI HISTONES ANTIBODIES
ANTI HISTONES ANTIBODIES NOT DETECTED NOT DETECTED
ANTI CENTROMERE ANTIBODIES
ANTI CENTROMERE ANTIBODIES NOT DETECTED
ABS TO EXTRACTABLE NUCLEAR AG: SCL70 SCL70
IGG ANTIBODIES NOT DETECTED
ABS TO EXTRACTABLE NUCLEAR AG: JO1
JO1 ABS IMMUNOBLOT NOT DETECTED
She doesn’t have rash, difficulties in going under sun. she does stiffness when she sits at one place for long time.
Her C3, C4 is normal and DS DNA is negative.
Can you pl advise what shpuld be done. She is really suffering since last so many years. Some time she feels ok and some time she can't even walk. As per doctor she has lupus at mild stage.
Regards
Lokesh
[size=]
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P.Bear R.N.
Research Staff
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Posted: Thu Aug 7th, 2008 00:52 |
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Lokesh,
High levels of 1,25-D inhibit the conversion of vitamin D into 25-D resulting in a low level of 25-D. Your wife's 25-D of 7.03ng/ml is quite low for someone who has not been avoiding ALL sources of Vitamin D. This suggests that her actual 1,25-D is high and the measurement of 15.1pg/ml is a false low. The likely reason is sample mishandling. I see nothing in your wife's clinical picture to justify this low level of 1,25-D. Extremely low levels (below 15pg/ml) suggest a severe viral infection such as AIDS or hepatitis. Has she been tested to rule out these?
Although levels above 12pg/ml represent a dominant Th1 inflammatory response and disproves a dominant Th2 response, the population average is 25-29 pg/ml and it is above-average 1,25-D levels (hypervitaminosis-D) that cause many troublesome symptoms.
Your wife's D-tests are ambiguous, but her diagnosis and symptoms would seem to indicate Th1 inflammation. Please see Symptoms of Hypervitaminosis-D and you may recognize a few more. You will not get well and your health will continue to deteriorate if you don't treat the underlying bacterial cause of Th1 inflammation with the MP. Please see Is the MP an applicable treatment for my disease?
You have the option to retest (which isn't necessary unless Doc insists) or to do a therapeutic probe which is our recommendation.
Most supplements and many medications must be avoided on the MP. It is our position that steroids will only make Lupus worse in the long run. If she is too sick sometimes to walk at "mild" stage of disease imagine how much worse moderate from of "lupus" would be.
also might be interested in:
THYROID DISEASE and Th1 inflammation
Our clinical study is temporarily closed to enrollment. As vacancies occur, we will admit subjects based on an application. To obtain an application forum, please send an email to marshallprotocol2@yahoo.com with 'request MP application' in the subject line.
best, P.B.
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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lokesh
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| Posts: | 5 |
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Posted: Sun Aug 10th, 2008 21:09 |
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Hi
Thanks for your response
We have done AIDS and Hepatitis tests in last one year several times but it was always negative. My wife has gone for those tests again and results will be ready in a day or two.
I want to know what does low level of 25D and 1,25D indicate. In my wife’s case Vitamin D level is low and MP helps in reducing the D level. Does she really need MP?
You also mentioned controlling D level by not taking diet which has Vitamin D. Should it be applied to my wife’s as well even if her D level is already low?
My understanding is patient should take Benicar (40 mg after every 6 hours) and then Minocycline (25 mg after every 48 hours) should be taken. But I am not able to understand for how long patient should be on Benicar before starting Minocycline.
And also for how long patient should take Benicar and Minocycline?
For how long Patient will have side affect of the medicine?
What will be the affect of Benicar and Minocycline on kidney? My wife was diagnosed with nephritic syndrome last year.
Thanks - Lokesh
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P.Bear R.N.
Research Staff
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Posted: Sun Aug 10th, 2008 22:37 |
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Lokesh, I believe that your 1,25-D test was almost certainly in error if your wife does not have a serious viral infection like HIV or hepatitis. You have the option to retest your wife (which isn't necessary unless Doc insists) or to do a therapeutic probe which is our recommendation.
Patients usually take the Benicar for a couple of weeks before adding the Mino. They are urged to move to adding second antibiotic after 3-4 months. Immunopatholgy can effect renal labs, but Benicar is renoprotective.
See the details to discuss with your Dr in this FAQ.. My kidney function tests are worse since I started the MP. What should I do? You will see there that the fluctuations are due to Immunopathology. More accurate testing may be needed. These tests 24 hour Creatinine Clearance and glomerular filtration rate(GFR) provide a more accurate assessment of kidney function. They are often normal when creatinine and BUN are high.
The aim or the key is for you to achieve and maintain tolerable symptoms (physically, mentally, and emotionally) and blood tests by adjustment of your meds dosing and schedule as suited individually to you within the guidelines.. managing all aspects of MP. ie eg including adjusting your meds, avoiding light and D and etc..
best, P.B.
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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