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Tickbite
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| Joined: | Sun Oct 21st, 2007 |
| Location: | Tulsa, OK, USA |
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Posted: Thu Jan 17th, 2008 13:52 |
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Researchers Solve First Structure of a Key to Intact DNA Inheritance
Bacteria, including S. Aureas, Use Mechanism to Spread Antibiotic Resistance
http://tinyurl.com/34j55f
"Because the segregation systems are essential for the retention of these multidrug resistant plasmids, they represent wonderful drug targets."
I wonder if immunopathology results from the destruction of plasmids alone? Sorry for the huge picture.
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Phase 3, MP since 6/06, "Lyme Meningitis Fatigue Syndrome"
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GeorgeinRollaMO
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| Joined: | Sat Oct 20th, 2007 |
| Location: | Rolla, Missouri USA |
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Posted: Thu Jan 17th, 2008 16:22 |
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Trusting that this will be a discussion opener for some folks that would like to learn and dazzle their medical doctor with molecular modeling. 
Wishing all wellness!!! 
Dark Vader... aka, George
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Borreliosis (but really Th1 inflammation). Start D values, July '04, 125D/57, 25D/61...over supplementation with D (fish oil).
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Claudia
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Posted: Sun Jan 20th, 2008 14:58 |
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How can anything so beautiful be so nasty?!
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MP from March 2006; Now in Phase III; Dx Thyroiditis; arthritis; eye irritation & glaucoma; history of CFS (1988-92);Kidney & bladder probs. Making steady progress toward recovery
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GeorgeinRollaMO
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Posted: Sun Jan 20th, 2008 19:32 |
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Claudia,
Come now, where is your scientific training???? 
That is an artist's conception, not the actual picture of a plasmid.
I would bet it looks in actuality just as bad as its known reputation.
Wishing all wellness!!!
Dark Vader...aka, George
____________________
Borreliosis (but really Th1 inflammation). Start D values, July '04, 125D/57, 25D/61...over supplementation with D (fish oil).
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Claudia
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Posted: Mon Jan 21st, 2008 01:12 |
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Hey, I'm just a girl... what do I know about science? oooh! Plasmid jewelery!!! cool.
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MP from March 2006; Now in Phase III; Dx Thyroiditis; arthritis; eye irritation & glaucoma; history of CFS (1988-92);Kidney & bladder probs. Making steady progress toward recovery
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Tickbite
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| Joined: | Sun Oct 21st, 2007 |
| Location: | Tulsa, OK, USA |
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Posted: Tue Jan 22nd, 2008 13:08 |
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George,
This thread was re-activated over in Dr. Marshall's perspective.
The picture is not an artist's conception. Please read the link!!!!!!! or the abbreviated below;
"The researchers used a technique called X-ray crystallography to discern the structure of both proteins connecting to the plasmid DNA. This technique first requires purification and crystallization of the protein or, in this case, the more challenging DNA-protein complex structure. These are usually the most difficult steps of the process.
Next, the crystal sample is mounted on a tiny loop in an X-ray diffractor and X-rays are beamed through it. Bending around the lattice of atoms in the crystal, the X-rays produce a diffraction pattern, which can be seen as a dot pattern on a monitor.
A state-of-the-art X-ray diffractor shoots a different angle of the crystallized protein every few minutes. Taking between 180-300 images will produce 100,000 to 300,000 data points.
Mathematical analysis of those points reveals a three-dimensional structure. The first image is an electron density map, which illustrates a protein's hills and valleys based on the position of the electrons of the atoms that compose the complex. This leads to the more exotic ribbon diagram, a spiraling, looping almost skeletal representation of the complex's crucial components.
The researchers used the Advanced Light Source (ALS) synchrotron at the U.S. Department of Energy's Lawrence Berkeley National Laboratory a fast, powerful diffractor that shoots a new diffraction pattern every half second, to solve this structure."
it's the same stuff Trevor is doing......come on man! where's your head!!!!!
NICE CLAUDIA!!!!!!!!!!!!!!!!! HAHAHA AWESOME.
Last edited on Tue Jan 22nd, 2008 13:12 by Tickbite
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Phase 3, MP since 6/06, "Lyme Meningitis Fatigue Syndrome"
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GeorgeinRollaMO
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Posted: Tue Jan 22nd, 2008 16:05 |
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Thanks, Greg!!!!
Now everybody knows how it is done.
Wishing all wellness!!!
Dark Vader...aka, George
____________________
Borreliosis (but really Th1 inflammation). Start D values, July '04, 125D/57, 25D/61...over supplementation with D (fish oil).
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