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believer
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Posted: Mon Nov 10th, 2008 00:52 |
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First I would like to say that I am certain that I have a progressive chronic inflamatory illness that doctors tell me to "just for get about!" Can you believe that!
So I am glad to find this site. My question is tho....if it is an issue of bacteria + vitamin d excess why is it that people who live in tropical places where the sun is constantly out and bacteria of all kinds abound all year long are not as sick with these illnesses as we in the North?
I don"t meet anywhere near as many sick people in the sun belt as I do up here in Canada?
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Rico
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Posted: Mon Nov 10th, 2008 01:15 |
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Is it possible that tropical places don't fortify their entire food chain with Vitamin D? Is the population in the tropics encouraged to supplement with Vitamin D as it is in northern countries such as Canada? If one believes that increased Vitamin D levels lead to a suppressed immune system opening one up to all sorts of infection, then perhaps the immune systems of people in the tropics can deal with what bacteria may be present, someting that probably can't be said in countries where people saturate themselves with Vitamin D. These are factors to consider...
You should take the time to read some of the material found here...
Bacteria and Th1 Inflammation-Basic Information
Vitamin D-Basic Information
Last edited on Mon Nov 10th, 2008 01:22 by Rico
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believer
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Posted: Mon Nov 10th, 2008 03:28 |
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Hi Rico..thanks for the reply....what Iam saying is that those people live in the sun CONSTANTLY that would create equal portions of vitamin D without the fortification process....
Perhaps it is vitamin D that is not from the sun that does it?
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JoshR
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Posted: Tue Nov 11th, 2008 13:18 |
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| Sun exposure generally does not result in the very high levels of 25-D that ingested supplements can produce. See Vitamin D metabolism and Th1 inflammation.
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Dr Trevor Marshall
Research Team
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Posted: Tue Nov 11th, 2008 17:14 |
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people who live in tropical places where the sun is constantly out and bacteria of all kinds abound all year long are not as sick with these illnesses as we in the North
As somebody who lived (and taught) in Papua New Guinea I will state categorically that it is not true to think there is less sickness in the tropics. The life span is much shorter there. The diversity of microbes is, however, different from those in the West, and therefore there are less of "our diseases" present...
There are so many misleading studies about disease incidence published by academics living in The West, academics who promulgate idiotic notions without having a clue what they are doing. Just look at the life expectancy. Can you see a consistent pattern here? What more does one need to know...
http://en.wikipedia.org/wiki/Life_expectancy
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believer
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Posted: Tue Nov 11th, 2008 18:09 |
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Dr Trevor Marshall wrote: people who live in tropical places where the sun is constantly out and bacteria of all kinds abound all year long are not as sick with these illnesses as we in the North
I understand that there are a whole lot more illnesses around the world and that the world suffers from more diseases than here. I am specfically refering to the type of diseases that are caused by th1, chrones, inflamatory, chronic arthrytic diseases etc...not typhoid and polio dengue fever etc. The over all unwellness that North Americans suffer from that is likely th1
Last edited on Tue Nov 11th, 2008 18:16 by
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Dr Trevor Marshall
Research Team
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Posted: Tue Nov 11th, 2008 18:19 |
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Please see my UCLA presentation on "Disease of the Aging" 
http://vimeo.com/1268542
Th1 disease is everywhere, only the specific metagenome and and healthcare change from place to place.
There are more details on diversity of the human metabolome in my upcoming keynote for Gene 2008 in early December including this slide:...
Last edited on Tue Nov 11th, 2008 18:24 by Dr Trevor Marshall
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Cynthia Schnitz
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Posted: Wed Nov 12th, 2008 01:59 |
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Are there any any titles for the coordinate axis? I looked up the article, but could only get the abstract, and there wasn't enough info in it to determine the coordinates. I am sure others working in the same field would know what they were., but would the average doctor know what the coordinates were?
Cynthia
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Phase1 10-27-08, Phase2 12-16-08, 125D:47, 25D:43;29;tbd, TriEst 1.25mgX2pd, Ca&Mg(as rqd), Calcium anomaly-gone in 3 wks of MP, Spondylitis, early Macular degeneration, early diverticulosis, Type II diabetes (unconfirmed), returning sense of smell
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Dr Trevor Marshall
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Posted: Wed Nov 12th, 2008 04:19 |
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Hmmm, the average Doctor wouldn't be able to interpret the coordinates if they were printed (no offense to the special Docs reading this, of course). The coordinates are derived from the Mass Spectrometer output with a very complex algorithm which looks for specific metabolites that come from Bacterial species only. The metabolites tracked here are not created by the Human genome.
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markt9452
Member
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Posted: Wed Nov 12th, 2008 12:13 |
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That's really interesting. I have seen that sort of visual data representaton before in a study that compared visual characteristics of Oak Tree species to the actual genomic data.
The conclusion was that you can not positively identify an Oak tree visually - You have to look at the genome as what appears to be one species is in many cases actually another when the genome is analyzed.
Basically a tree that looked like a red oak in every way could actually be a red, black, pin or shumard or a mix of them.
I guess the point of this post is that you have to take the genomic data into consideration because things are not always what they seem to be.
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markt9452
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Posted: Wed Nov 12th, 2008 12:43 |
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I think it would be really interesting to get a higher resolution digital copy of that map plug it into a GIS program like ESRI's ARC GIS and then overlay some different geological layers like "soil type" or "extent of maximum glacial advance" for example just to see if there are any obvious patterns on a more regional scale that could help identify specific metagenomes.
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jcwat101
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Posted: Thu Nov 13th, 2008 05:29 |
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I think the answer is likely to be complex and probably a lot to do with pathogen distribution.
But, in any case, here is a counter example. People in Mexico tend to get RA on average, about 12 years earlier than in Canada:
Ramos Mexican RA onset earlier than Canada
Joyce Waterhouse
Last edited on Thu Nov 13th, 2008 05:30 by jcwat101
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markt9452
Member
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Posted: Thu Nov 13th, 2008 13:27 |
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I think the answer is likely to be complex and probably a lot to do with pathogen distribution
I'm thinking that the opportunity for distribution would have occurred after the glacial recession in North America and that the reasons for this distribution opportunity effect are geological.
These events are cyclical, linked to fluctuations in solar radiation, resulting in large areas of exposed soil, population migrations and frequently involve large scale extinction events. Sometimes of entire taxonomic families.
Does this have anything to do with the spread of TH1 microbiota or help us understand why these things happen in populations? I don't really know but I think it might.
http://www.physorg.com/news145604162.html Scientists identify first mammal for which disease led to extinction
The data indicated the presence of a protozoan known as Trypanosoma lewisi. A related organism can cause sleeping sickness in humans.
Last edited on Thu Nov 13th, 2008 15:38 by markt9452
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