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Inspiro
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| Location: | Houston, Texas USA |
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Posted: Thu Aug 14th, 2008 21:00 |
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Hello to all this is my first post. Additionally, thank you members, advocates & moderators for being out there.
My Ig & IgG Subclasses are virtually all low for the exception of Secretory IgA. I assume this is my body trying to cope with the primary infection and secondary co-infections. My questions: Could this ImmuneGlobulin status be aggrevated by D dysregulation and long term corticisteroid use ? I would guess yes since both D & Cortisol (currently weaning with Benicar blockade) are immunosuppresive. Your thoughts ??
Secondly, would ImmuneGlobulin therapy be contraindicated while on MP ? I know that Ig therapy has cancer & other protective properties. However, I have had a life threatening Herx reaction ( IP - Sepsis) while attempting Neurotoxin binding therapy ( Rx med) post Lyme treatment. Knowing about the MP & the immune modulating effects of Benicar & Mino. I would never attempt such a therapy again. In addition, I do not ever want to be in that life threatening situation again.
Could Ig therapy precipitate a significant or even life threatening IP ?? I suspect yes but need some definitive input.
FYI: Since eliminating high D foods/sun exposure & Noirs ten days ago & Benicar two days my symptomology ( IP) has reduced sig. to a much tolerable level.
Thanks MP !! Inspiro
[paragraph spacing added to improve legibility]
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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JRFoutin
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Posted: Thu Aug 14th, 2008 21:38 |
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Inspiro,
Welcome to the general questions site to learn about the Marshall Pathogenesis and Marshall Protocol. This is your personal thread to ask all your questions. You will want to keep them together in one place for your own review and for continuity.
Your question is very similar to many who wonder about a specific test marker they've studied elsewhere, or a particular treatment that made them feel better for a while. You might even see specific details for these very popular details in a search on the study site but that really isn't the point.
Essentially, you would like to know if the Marshall Protocol requires omitting protocols you have used in the past. Here are some helpful information sets:
Why do I have to stop my alternative treatment and avoid most supplements?
Safety warning
The MP is a singular therapy that targets the immune system. Your sepsis response may be reminder enough to stick to just the MP, now that you have already begun Benicar.
Although many find their first responses on Benicar are not so fun, a certain percent will feel better on Benicar alone. I sure did, but then I started to experience the expected response pattern after the first couple of weeks, and clearly during phase 1, per info in the Marshall Protocol Phase 1 guidelines.
You may want to chart your progress so you and your doctor can look at long term trends that can be missed with day to day notes.
I also recommend you frequently read Amy Proal's http://www.Bacteriality.com site. A good place to start is her recent presentation in vimeo (movie) format. Here is Amy's description and the link:
"In the following video, I explain the science that forms the backbone of the Marshall Protocol in simple terms. I discuss the bacteria implicated in causing chronic inflammatory disease, and explain how these pathogens affect the immune system. I also describe the basics of the treatment itself, providing information that any patient who plans to start the Marshall Protocol, or any doctor planning to put a patient on the MP, should understand. My narration is accompanied by slides with pictures and images of the pathogens and molecules I discuss. The video is 89 minutes."
http://bacteriality.com/2008/05/07/mpintro/
Best to you Inspiro--Janet
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12/99:Sarc, 9/00:noPred, Mar05:no-D+lo-lght+NoIRs, 8/09/05 began MP. MP ph3 yr3 and getting better every day.
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Inspiro
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Posted: Fri Aug 15th, 2008 00:10 |
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Janet,
Thank you for getting back to me so fast. I am downloading the text from bacteriality.com. It looks very interesting.
I am confident the MP is the correct direction for treatment and healing. I have traveled all over the US & attempted so many different therapies with little returns. I was even treated by one of the prominent Lyme Disease clinics in the US with high dose IV abx for a year. I was feeling worse than ever post treatment and the study researchers left clinical practice for additional laboratory research on CWD/ Th1 pathogens. I feel the Lyme community, including very compassionate & dedicated Lyme Literate Medical Doctors ( LLMD), have missed the big picture of immune restoration. I am living proof that abx alone do not cause immune competence. The MP is the only treatment I have found that addresses immune restoration.
Currently my big "task" is weaning from Cortef. I am following the MP " Weaning From Steroids" to the letter. I never appreciated, until now, how destructive and difficult it is to get off corticosteroids. I bel. the Benicar will make the process more tolerable. It's sobering to think that with Cortisol I was effectively giving the Th1 pathogens a free pass to colonize with little resistance.
Sincere Thanks ! Take Care.
I
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Inspiro
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Posted: Fri Aug 15th, 2008 16:30 |
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Hello,
Before starting the MP I was briefly on a Ph2 abx. ( One tablet a day for four days ) When it is time for me to progress to Ph2 ( I'm still early MP as I'm weanig from Cortef w/ help from Benicar) in perhaps four to eight months will the Ph2 abx still be viable in killing Th1 pathogens ?? To my understanding the MP addresses this bacterial resistance issue with the very strict abx and pulsed dosing schedules. I would hope I didn't ruin an important Ph2 abx because of four days. Except for this four day course I haven't been exposed to this particular abx for approx. five years.
Just a note I did wait several weeks for the Abx to leave my system before beginning the Benicar blockade. I did not want to have a massive, intolerable Herx - IP.
I have been studying and printing out many, many pages of pre MP and MP Ph1 guidelines so as to do this protocol as exact as possible. My wife and I this morning have been putting up special UV Blockade curtains on our many windows. I know and trust the initial changes and temporary sufferring will bring about huge returns in the future.
Thanks,
Inspiro
Moderator Note: Your post has been merged into your own personal thread for continuity. Thank you.
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Julia
Advocate (on leave)
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Posted: Fri Aug 15th, 2008 19:25 |
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Inspiro,
Don't worry about antibiotics taken pre-MP. It's a very different thing when you have the 'Benicar blockade' in place, and when you take the abx in tiny, pulsed doses. Many members have had many abx before they found the MP, but on the MP they react to the same meds in a totally new way.
Julia 
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Inspiro
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Posted: Sun Aug 17th, 2008 19:48 |
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Hello,
Just an update on my Benicar blockade and weaning from steroids process.
As stated in the MP lit. & guidelines I can "feel" my immune function kicking in and am experiencing IP - Herx. I'm not even on the Mino. as of yet. It is remarkable to not only study but experience the changes Benicar provides in immune fxn.
I do have a question for anyone listening. Do many members experience tingle. sensations, globally, as IP increases ? I know we all Herx in various patterns according to Th1 pathogenic involvement. Before MP one of my most painful IP rxn was likened to " small nails" in my feet. Needless to day it was a VERY unpleasant four weeks.
Any thoughts or comments ?
Sincere Thanks,
Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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JRFoutin
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Posted: Sun Aug 17th, 2008 22:32 |
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Kelton,
Thank you for asking an important question about nerves based on the response to IP that you are experiencing.
Like all other body tissues, nerves are often impacted in Th1, even if it isn't the dominant reason for which anyone might have started the MP.
Will the MP treat paresthesia and neuropathy?
Best to you Kelton--Janet
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12/99:Sarc, 9/00:noPred, Mar05:no-D+lo-lght+NoIRs, 8/09/05 began MP. MP ph3 yr3 and getting better every day.
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Inspiro
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Posted: Sat Aug 23rd, 2008 20:32 |
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Hello,
I 've been following the MP " Weaning from Steroids" information and as indicated am experiencing more IP. I have increased my Benicar dosing per "Controlling IP" guidelines but am still having some significant herx. I am now considering adding frequent low dose Mino. as an additional IP. anti-inflammatory, modulating tool.
Since this is my first experience w/ Mino. as an anti-infllamatory what can I expect ? I am not ready to use Mino. as an immune enabeling pulse until steroid weaning process is complete plus two weeks. I have about six to eight weeks of the steroid weaning process on the calendar.
Some of my more profound symptoms are Cardiac Palpitations and skin outbreaks. Anxiety is also on the rise.
I have read Contolling Cardiac IP but am needing some member experience input.
Thank you all for your incredible help and information !
Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Julia
Advocate (on leave)
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Posted: Sat Aug 23rd, 2008 22:22 |
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Kelton,
If symptoms approach intolerable, assess your natural light exposure, assess your symptoms and use your personal tool kit to be sure symptoms are not due to other factors besides immunopathology (natural light exposure, lack of rest, exercise, diet, etc) that can be modified to reduce symptoms asap.
The recommended first step when symptoms become intolerable is to take an extra 40mg Benicar immediately. Chew the tablet and place it under your tongue for faster absorption and relief. See How to make Benicar act faster.
If intolerable symptom/s persist, increase Benicar to every fours hours around the clock until symptoms are tolerable.
Occasionally, sudden reduction of daylight and dietary vitamin D can cause symptoms to rise to intolerable. See Should I avoid sun exposure and vitamin D while I'm waiting to start the MP?
If all these attempts to dampen IP fail, you could consult with your doctor about frequent minocycline, but it is not something to be undertaken lightly.
Julia 
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Inspiro
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Posted: Sat Aug 30th, 2008 16:20 |
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Is it ok to take OTC pain medications ( Tylenol, Aspirin & Advil) while on the MP ??
What about Alka Seltzer and the Rx Ultram ??
Thanks - Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Julia
Advocate (on leave)
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Posted: Sat Aug 30th, 2008 17:51 |
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Kelton,
Please see PAIN CONTROL.
If by Alka Seltzer you mean the antacid formula for indigestion, go easy. (My personal, strictly unofficial recommendation is to try a teaspoon of cider vinegar in half a glass of lukewarm water. This sounds crazy, adding acid to acid, but it works  Neutralising the excess acid with an antacid just makes the stomach produce more.)
Julia 
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Inspiro
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Posted: Mon Sep 1st, 2008 20:21 |
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I've noticed when I'm Herxing at certain times I suffer from "Restless Leg Syn.". Is this just part of the toxic Th1 pathogenic die-off ?? Not to sound like a wimp but can anything be done to reduce RLS sx ?? 
Thanks - Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Julia
Advocate (on leave)
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Posted: Mon Sep 1st, 2008 20:54 |
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Kelton,
Yes, I'm afraid RLS is a common Th1 symptom and herx. Some people find it helps to reduce your intake of salicylates, especially in the evening if it's keeping you awake at night. If you google salicylates in foods you can find various tables - the worst things are tea and most fruits. RLS does go away... and come back, and go away... eventually for good 
Julia 
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ALWAYS CONSULT A PHYSICIAN
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Inspiro
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Posted: Tue Sep 2nd, 2008 21:36 |
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Hello,
I'm currently in the final 4-6 weeks of weaning from cortisol. I've noticed each time I reduce the dosage I have some pretty intense anxiety attacks and IP. Is this normal ?? Once I level off at a current dosage anxiety and other sx seems to decrease. Could a good deal of this(sx) be attributed to the whole weaning from steroids process? I am following the "Weaning from Steroids" guidelines.
Also, I'm using 15 watt soft white bulbs for my low lux environment( cave). Is this sufficient ??
Thanks = Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Julia
Advocate (on leave)
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Posted: Tue Sep 2nd, 2008 23:24 |
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Kelton,
If symptoms are approaching intolerable, assess your natural light exposure, assess your symptoms and use your personal tool kit to be sure symptoms are not due to other factors besides immunopathology (natural light exposure, lack of rest, exercise, diet, etc) that can be modified to reduce symptoms asap.
The recommended first step when symptoms have gone past tolerable is to increase Benicar. Do not wait. Take an extra oral 40mg immediately. A hot drink (sugar-free chocolate or weak tea) will help the pill reach the stomach quickly.
Chewing the tablet and placing it under the tongue will promote faster absorption and quicker symptom relief. See How to make Benicar act faster.
If an extra oral or sublingual dose of Benicar does not work, do not assume that increasing Benicar to every 3-4 hours will not work.
If intolerable symptom/s persist, increase oral 40mg Benicar to every three or fours hours around the clock (set an alarm and use a dosette to avoid error). Continue until symptoms are tolerable.
How can I control my anxiety and depression?
15watt should be plenty dim enough. The aim is a romantic glow, not a batty cave 
Julia 
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Inspiro
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Posted: Fri Sep 5th, 2008 17:13 |
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Hello,
This is a medical question. The other day I went to my Doctor for a follow up appointment. Unfortunately, I grabbed my "inside" Noirs by mistake and by the time ( approx. 1 hour) I arrived my resting pulse was 111. My B/P was stable at 109/67. I did start sublingual Benicar per MP guidelines and sure enough the cardiac sx began to resolve. After several doses ( sub. & oral) over approx. 4-6 hours the cardiac sx were completely resolved.
Because of my potential Th1 1 cardiac involvement my Doc. suggested the beta blocker Inderal ( propranolol) at a low dose & prn. Is it ok to take propranolol as long as it IS NOT combined with the diuretic HCT ?? I searched the Medications To Avoid List and the only contraindication is the propranolol/hct combination. My Doctor just wants to be on the safe side considering potential future aryth./pulse sx.
I'm going to see a Cardiologist next week to determine cardiac fxn. I'm also learning how critical it is to control light exposure - eye & skin.
Thanks - Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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Dr Trevor Marshall
Research Team
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Posted: Sat Sep 6th, 2008 11:54 |
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Kelton,
Any med which affects the operation of the heart will affect the healing of the heart.
Some members have taken beta-blockers, but it is yet another drug you have to balance, and get the dosing right. Have a chat with Doc about whether a beta-blocker is really necessary. A higher dose (40mg q4h) of Benicar is safer, and will probably do a better job.
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Inspiro
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Posted: Wed Sep 10th, 2008 18:39 |
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Dr. Marshall thank you so very much for your reply to my previous post. I did start the Benicar 40mg ( q4h) & added a few 20mg sublingual with amazing results. My cardiac sx have abated and is being controlled by this dosing schedule. My resting pulse is in the 60's or 70's and my b/p ranges from SYS 102 - 112 over DIA 60-70 without any negative side effects.
This is a question for anyone who understands the clotting system. I know the clotting system can be activated & vigilant in Th1 diseases. To my understanding Benicar is an incredible protective factor in this physiological process. At times is it prudent to add any other protective measure ?? I am concerned about my body throwing off clots.
My latest labs ( 7/03/08) without Benicar: FIBRINOGEN Activity (Clauss) 246 mg/dl with the reference range being 175-425 mg/dl.
My THROMBIN - ANTITHROMBIN ( TAT complex) is high at 17.0 mcg/L. The reference range being LESS THAN 4 .
My LIPID PANEL was excellent.
Thanks - Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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P.Bear R.N.
Research Staff
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Posted: Thu Sep 11th, 2008 06:29 |
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Inspiro, We do not encourage or permit the use of heparin or coumadin unless physician very closely monitors clotting times. Although TAT complex is often elevated in conditions of chronic inflammation this lab is rarely done and I do not know what level of elevation would require an intervention to prevent clotting. If you have not had problems with clotting so far this might be a good sign; but you would have to talk with you hematologist. We have had many hundreds of people so far progress on the Marshall Protocol without any anti-coagulation.
Is it safe to take anticoagulants while on the Marshall Protocol?
Best, P.B.
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Inspiro
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Posted: Sat Sep 20th, 2008 16:47 |
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Hello - It's great to post again ! Hurricane Ike really hit us hard here in Houston.
I have an update in my MP status/progression and a question.
I have now completed my "weaning from steroids" process and will begin pulsed Mino. in about two weeks. Could the Moderator change my thread topic to "Inspiro's Questions - MP Independently PH1" ?? Thanks.
Just a note - Half of my weaning from steroids was w/out Benicar and the other half with Benicar. The difference was like night and day. The Benicar made it so much easier ! Also, my Doctor has been amazed at the effects of Benicar on my very dysfunctional endocrine system. Since being on the Benicar my endocrine labs have risen across the board. Each week or two I have to lower my Slow Release T3 dosage. Six weeks ago I was taking 75mcg SR T3 - daily & now I'm at 10mcg SR T3 daily.
My question - Because of Hurricane Ike I had to spend a great deal of time outside. I covered up as much as possible and put on massive amounts of sunscreen (Neutrogena 85spf "stabilized" formula) and to a lesser degree Ketoconazole Cream. I could def. feel the increase sx due to sun exposure. I increased Benicar 40mg to every three hours with a good deal of success. I did this for three days and really didn't have any adverse side effects from this dosing schedule. Because of my intense increase in sun exposure and consequently higher D levels would it be prudent to wait an additional week or two - even after the two week weaning f/ steroids waiting period - before beginning Mino. ??
My wife and I have moved due to extensive damage to our home. Consequently, I'm back into a 30 low lux environment with air conditioning - Thank God !! Highs in the upper 80's and low 90's with 75+ % humidity can be intense.
Thanks - Kelton
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Chron. Lyme(PTLDS)/CFIDS/Hashimoto's Thyroid/ Polyneuropathy/Cataracts/Noirs/Benicar(8/13/08)/Mino./Ultram/Trazadone/Valium/ 125D68&25D42-Quest frozen(7/3/08)/30 Lux Home Env.
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